List of Publications:
August 13, 2022
To view the most up-to-date publications visit Dr. Opri’s pubmed:

Cole ER, Opri E, Borgheai SB, Han Y, Isbaine F, Boulis N, Willie JT, AuYong N, Gross RE, Miocinovic S. An algorithmic procedure for measuring deep brain stimulation-induced capsular activation using motor evoked potentials. J Neural Eng. 2025 Dec 30;22(6):066044. doi:10.1088/1741-2552/ae2e8b PubMed PMID: 41406617; PubMed Central PMCID: PMC12749111.

Lampert F, Baker MR, Jensen MA, Ayyoubi AH, Bentler C, Bowersock JL, Esteller R, Herron JA, Johnson GW, Kipke DR, Kovach CK, Kremen V, Mivalt F, Neimat JS, Netoff TI, Opri E, Rockhill A, Rosenow JM, Sellers KK, Staff NP, Swamy CP, Viswanathan A, Schalk G, Denison T, Hermes D, Ince NF, Brunner P, Worrell GA, Miller KJ. Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development. J Neural Eng. 2025 Dec 19;22(6):061005. doi:10.1088/1741-2552/ae2359 PubMed PMID: 41285049; PubMed Central PMCID: PMC12715846.

Deligani RJ, Opri E, Risk BB, Goldstein F, Factor SA, Higginbotham LA, Swann NC, Miocinovic S. Cortical beta power modulation is asymmetric and reduced during movement execution and inhibition in Parkinson’s disease. Neurobiol Dis. 2025 Dec;217:107195. doi:10.1016/j.nbd.2025.107195 PubMed PMID: 41248810; PubMed Central PMCID: PMC12715724.

Borgheai SB, Howell B, Isbaine F, Noecker AM, Opri E, Risk BB, McIntyre CC, Miocinovic S. Evaluation of DBS computational modeling methodologies using in-vivo electrophysiology in Parkinson’s disease. Brain Stimul. 2025;18(6):1996–2007. doi:10.1016/j.brs.2025.10.022 PubMed PMID: 41161414; PubMed Central PMCID: PMC12640560.

Opri E, Isbaine F, Borgheai SB, Bence E, Deligani RJ, Willie JT, Gross RE, Au Yong N, Miocinovic S. Deep brain stimulation-induced local evoked potentials outperform spectral features in spatial and clinical STN mapping. J Neural Eng. 2025 Aug 8. doi:10.1088/1741-2552/adf99f PubMed PMID: 40780240; PubMed Central PMCID: PMC12395123.

Borgheai SB, Opri E, Isbaine F, Cole ER, Jafari Deligani R, Laxpati NG, Risk BB, Willie JT, Gross RE, AuYong N, McIntyre CC, Miocinovic S. Neural pathway activation in the subthalamic region depends on stimulation polarity. Brain Commun. 2025;7(1):fcaf006. doi:10.1093/braincomms/fcaf006 PubMed PMID: 39980742; PubMed Central PMCID: PMC11839843.

Neudorfer C, Butenko K, Oxenford S, Rajamani N, Achtzehn J, Goede L, Hollunder B, Ríos AS, Hart L, Tasserie J, Fernando KB, Nguyen TAK, Al-Fatly B, Vissani M, Fox M, Richardson RM, van Rienen U, Kühn AA, Husch AD, Opri E, Dembek T, Li N, Horn A. Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks. Neuroimage. 2023 Mar;268:119862. doi:10.1016/j.neuroimage.2023.119862 PubMed PMID: 36610682.

Cagle JN, Okun MS, Cernera S, Eisinger RS, Opri E, Bowers D, Ward H, Foote KD, Gunduz A. Embedded Human Closed-Loop Deep Brain Stimulation for Tourette Syndrome: A Nonrandomized Controlled Trial. JAMA Neurol. 2022 Oct 1;79(10):1064–8. doi:10.1001/jamaneurol.2022.2741 PubMed PMID: 36094652; PubMed Central PMCID: PMC9468946.

Connolly MJ, Opri E, Miocinovic S, Devergnas AD. Meta-Bayesian Optimization for Deep Brain Stimulation. Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:1729–33. doi:10.1109/EMBC48229.2022.9871279 PubMed PMID: 36085828.

Yang JC, Bullinger KL, Isbaine F, Alwaki A, Opri E, Willie JT, Gross RE. Centromedian thalamic deep brain stimulation for drug-resistant epilepsy: single-center experience. J Neurosurg. 2022 Dec 1;137(6):1591–600. doi:10.3171/2022.2.JNS212237 PubMed PMID: 35395630.

Wong JK, Deuschl G, Wolke R, Bergman H, Muthuraman M, Groppa S, Sheth SA, Bronte-Stewart HM, Wilkins KB, Petrucci MN, Lambert E, Kehnemouyi Y, Starr PA, Little S, Anso J, Gilron R, Poree L, Kalamangalam GP, Worrell GA, Miller KJ, Schiff ND, Butson CR, Henderson JM, Judy JW, Ramirez-Zamora A, Foote KD, Silburn PA, Li L, Oyama G, Kamo H, Sekimoto S, Hattori N, Giordano JJ, DiEuliis D, Shook JR, Doughtery DD, Widge AS, Mayberg HS, Cha J, Choi K, Heisig S, Obatusin M, Opri E, Kaufman SB, Shirvalkar P, Rozell CJ, Alagapan S, Raike RS, Bokil H, Green D, Okun MS. Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury. Frontiers in Human Neuroscience. 2022 Mar 4;16. doi:10.3389/FNHUM.2022.813387 PubMed PMID: 35308605.

Middlebrooks EH, Okromelidze L, Wong JK, Eisinger RS, Burns MR, Jain A, Lin HP, Yu J, Opri E, Horn A, Goede LL, Foote KD, Okun MS, Quiñones-Hinojosa A, Uitti RJ, Grewal SS, Tsuboi T. Connectivity correlates to predict essential tremor deep brain stimulation outcome: Evidence for a common treatment pathway. NeuroImage Clinical. 2021 Jan 1;32. doi:10.1016/J.NICL.2021.102846 PubMed PMID: 34624639.

Cernera S, Alcantara JD, Opri E, Cagle JN, Eisinger RS, Boogaart Z, Pramanik L, Kelberman M, Patel B, Foote KD, Okun MS, Gunduz A. Wearable sensor-driven responsive deep brain stimulation for essential tremor. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation. 2021 Sep;0(0). doi:10.1016/J.BRS.2021.09.002 PubMed PMID: 34547503.

Howell B, Isbaine F, Willie JT, Opri E, Gross RE, De Hemptinne C, Starr PA, McIntyre CC, Miocinovic S. Image-Based Biophysical Modeling Predicts Cortical Potentials Evoked with Subthalamic Deep Brain Stimulation. Brain Stimulation. 2021 May;14(3). doi:10.1016/j.brs.2021.03.009

Eisinger RS, Cagle JN, Alcantara JD, Opri E, Cernera S, Le A, Torres Ponce EM, Lanese J, Nelson B, Lopes J, Hundley C, Ravy T, Wu SS, Foote KD, Okun MS, Gunduz A. Distinct Roles of the Human Subthalamic Nucleus and Dorsal Pallidum in Parkinson’s Disease Impulsivity. Biological Psychiatry. 2022 Mar 6;91(4):370–9. doi:10.1016/J.BIOPSYCH.2021.03.002 PubMed PMID: 33993998.

Molina R, Hass CJ, Cernera S, Sowalsky K, Schmitt AC, Roper JA, Martinez-Ramirez D, Opri E, Hess CW, Eisinger RS, Foote KD, Gunduz A, Okun MS. Closed-Loop Deep Brain Stimulation to Treat Medication-Refractory Freezing of Gait in Parkinson’s Disease. Front Hum Neurosci. 2021;15:633655. doi:10.3389/fnhum.2021.633655 PubMed PMID: 33732122; PubMed Central PMCID: PMC7959768.

Opri E, Cernera S, Molina R, Eisinger RS, Cagle JN, Almeida L, Denison T, Okun MS, Foote KD, Gunduz A. Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor. Sci Transl Med. 2020 Dec 2;12(572):eaay7680. doi:10.1126/scitranslmed.aay7680 PubMed PMID: 33268512; PubMed Central PMCID: PMC8182660.

Coronel MM, Martin KE, Hunckler MD, Barber G, O’Neill EB, Medina JD, Opri E, McClain CA, Batra L, Weaver JD, Lim HS, Qiu P, Botchwey EA, Yolcu ES, Shirwan H, García AJ. Immunotherapy via PD-L1-presenting biomaterials leads to long-term islet graft survival. Science Advances. 2020 Aug 1;6(35). doi:10.1126/sciadv.aba5573 PubMed PMID: 32923626.

Cagle JN, Deeb W, Eisinger RS, Molina R, Opri E, Holland MT, Foote KD, Okun MS, Gunduz A. Lead repositioning guided by both physiology and atlas based targeting in tourette deep brain stimulation. Tremor and Other Hyperkinetic Movements. 2020;10(1):1–7. doi:10.5334/tohm.140 PubMed PMID: 32775032.

Molina R, Hass CJ, Sowalsky K, Schmitt AC, Opri E, Roper JA, Martinez-Ramirez D, Hess CW, Foote KD, Okun MS, Gunduz A. Neurophysiological Correlates of Gait in the Human Basal Ganglia and the PPN Region in Parkinson’s Disease. Frontiers in Human Neuroscience. 2020 Jun 4;14. doi:10.3389/fnhum.2020.00194

Alcantara JD, Eisinger RS, Opri E, Kelberman M, Cagle JN, Gomez J, Foote KD, Okun MS, Gunduz A. Florida research open-source synchronization tool (FROST) for electrophysiology experiments. Journal of Neuroscience Methods. 2020 Jul 15;341. doi:10.1016/j.jneumeth.2020.108800 PubMed PMID: 32497676.

Cagle JN, Okun MS, Opri E, Cernera S, Molina R, Foote KD, Gunduz A. Differentiating tic electrophysiology from voluntary movement in the human thalamocortical circuit. Journal of Neurology, Neurosurgery and Psychiatry. 2020 May 1;91(5):533–9. doi:10.1136/jnnp-2019-321973 PubMed PMID: 32139653.

Eisinger RS, Cagle JN, Opri E, Alcantara J, Cernera S, Foote KD, Okun MS, Gunduz A. Parkinsonian Beta Dynamics during Rest and Movement in the Dorsal Pallidum and Subthalamic Nucleus. The Journal of Neuroscience. 2020 Apr 1;40(14):2859–67. doi:10.1523/jneurosci.2113-19.2020 PubMed PMID: 32107277; PubMed Central PMCID: PMC7117906.

Opri E, Hu W, Jabarkheel Z, Hess CW, Schmitt AC, Gunduz A, Hass CJ, Okun MS, Wagle Shukla A. Gait characterization for patients with orthostatic tremor. Parkinsonism and Related Disorders. 2020 Feb 1;71:23–7. doi:10.1016/j.parkreldis.2020.01.007 PubMed PMID: 31981995.

Opri E, Cernera S, Okun MS, Foote KD, Gunduz A. The Functional Role of Thalamocortical Coupling in the Human Motor Network. The Journal of Neuroscience. 2019 Aug 30;39(41):1153–19. doi:10.1523/jneurosci.1153-19.2019

Gunduz A, Opri E, Gilron R, Kremen V, Worrell G, Starr P, Leyde K, Denison T. Adding wisdom to ‘smart’ bioelectronic systems: a design framework for physiologic control including practical examples. Bioelectronics in Medicine. 2019 Mar 30;2(1):29–41. doi:10.2217/bem-2019-0008 PubMed PMID: 33868718; PubMed Central PMCID: PMC7610621.

Stanslaski S, Herron J, Chouinard T, Bourget D, Isaacson B, Kremen V, Opri E, Drew W, Brinkmann BH, Gunduz A, Adamski T, Worrell GA, Denison T. A Chronically Implantable Neural Coprocessor for Investigating the Treatment of Neurological Disorders. IEEE Trans Biomed Circuits Syst. 2018 Dec;12(6):1230–45. doi:10.1109/TBCAS.2018.2880148 PubMed PMID: 30418885; PubMed Central PMCID: PMC6415546.

Molina R, Okun MS, Shute JB, Opri E, Rossi PJ, Martinez-Ramirez D, Foote KD, Gunduz A. Report of a patient undergoing chronic responsive deep brain stimulation for Tourette syndrome: Proof of concept. Journal of Neurosurgery. 2018;129(2). doi:10.3171/2017.6.JNS17626

Rossi PJ, Shute JB, Opri E, Molina R, Peden C, Castellanos O, Foote KD, Gunduz A, Okun MS. Impulsivity in Parkinson’s disease is associated with altered subthalamic but not globus pallidus internus activity. Journal of Neurology, Neurosurgery & Psychiatry. 2017 Aug;88(11):968–70. doi:10.1136/jnnp-2016-315325 PubMed PMID: 28822983.

Almeida L, Deeb W, Spears C, Opri E, Molina R, Martinez-Ramirez D, Gunduz A, Hess CW, Okun MS. Current Practice and the Future of Deep Brain Stimulation Therapy in Parkinson’s Disease. Seminars in Neurology. 2017 Apr;37(2):205–14. doi:10.1055/s-0037-1601893 PubMed PMID: 28511261.

Shute JB, Okun MS, Opri E, Molina R, Rossi PJ, Martinez-Ramirez D, Foote KD, Gunduz A. Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome. NeuroImage: Clinical. 2016;12:165–72. doi:10.1016/j.nicl.2016.06.015 PubMed PMID: 27419067.

Rossi PJ, Opri E, Shute JB, Molina R, Bowers D, Ward H, Foote KD, Gunduz A, Okun MS. Scheduled, intermittent stimulation of the thalamus reduces tics in Tourette syndrome. Parkinsonism and Related Disorders. 2016 Aug;29:35–41. doi:10.1016/j.parkreldis.2016.05.033 PubMed PMID: 27297737.

Rossi PJ, Gunduz A, Judy J, Wilson L, Machado A, Giordano JJ, Elias WJ, Rossi MA, Butson CL, Fox MD, McIntyre CC, Pouratian N, Swann NC, de Hemptinne C, Gross RE, Chizeck HJ, Tagliati M, Lozano AM, Goodman W, Langevin JP, Alterman RL, Akbar U, Gerhardt GA, Grill WM, Hallett M, Herrington T, Herron J, van Horne C, Kopell BH, Lang AE, Lungu C, Martinez-Ramirez D, Mogilner AY, Molina R, Opri E, Otto KJ, Oweiss KG, Pathak Y, Shukla A, Shute J, Sheth SA, Shih LC, Steinke GK, Tröster AI, Vanegas N, Zaghloul KA, Cendejas-Zaragoza L, Verhagen L, Foote KD, Okun MS. Proceedings of the third annual deep brain stimulation think tank: A review of emerging issues and technologies. Frontiers in Neuroscience. 2016;10(APR):119. doi:10.3389/fnins.2016.00119 PubMed PMID: 27092042; PubMed Central PMCID: PMC4821860.